Bioinformatics scientist Interview Questions


Bioinformatics Scientist interview questions shared by candidates

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Marshfield Clinic
Bioinformatics Scientist was asked...5 June 2018

Can you manipulate bclfastq files?

2 Answers

I described the pipeline I constructed.

lots of script can do bclfastq, why ask this question?

Personal Genome Diagnostics

Do you feel you would fit in a culture of rapid-change?

2 Answers

I hedged my bets. I said that I was fine with rapid-change as long as the goals were clearly defined each time they changed. Less

Yes I do no I will be a good person for the position cause I'm a team player and I like meet different people Less

Pacific Biosciences

Asking me about NGS experience, general and w/ PacBio.

1 Answers

Described NGS functions in previous jobs.


Have you ever encountered batch effect or any technical effect. What was the impact on your data and how do you control for these unwanted variables.

1 Answers

Use the ComBat function from the SVA Bioconductor package to combat batch effect


how to convert SAM to BAM files?

1 Answers

samtools view -Sb >

Twist Bioscience

Some coding and statistics questions, some questions about NGS pipelines.

1 Answers

Did you have to do a drug test?


NGS data analysis workflow/pipeline and tools

1 Answers

The current "best" tools for differential expression analysis, e.g. DESeq2 and EdgeR, incorporate normalization factors accounting for library size and composition. Pointedly, these tools do not "just" normalize prior to analysis, they include the normalization factors as features within the model. If you are looking to utilize a neural network, hierarchical bayesian, or other type of machine learning approach to differential expression, determining the appropriate method of normalization will be a make or break point. Less

Intermountain Healthcare

Do you have experience in analyzing SNP's? If so, describe

1 Answers


JMI Laboratories

Why do you want to live in Iowa?

1 Answers

Never been in a place with real seasons. I'm sure I'd get sick of winters, but I have a strong belief in experiencing as many different places as possible. I think JMI laboratories is doing good work in anti-bacterial research and I want to be a part of that, the location isn't as important. Less


In round 1 they get an overall picture of you and your future goals and give you some idea about their work. Second round they will ask questions about your research and especially try to evaluate how your research can help their tech.

1 Answers

Just answer honestly with the pros and cons of your research and how it can be applied or not. Less

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