1. Working at home has a lot of upsides (less time wasted, more geographic flexibility, more scheduling flexibility - especially helpful for parents and other caregivers), but it also has its challenges. You need to be ready to define clear lines between work and life, to be intentional about building rapport with your coworkers (through silly pigeon GIF threads, book clubs, scheduled small talk time in meetings, etc.), and to ask for help when things aren't working.
2. We have the opportunity to make such a big impact precisely because this research area is so neglected. Some people might not like working in an emerging field. It means you have to constantly be an ambassador for your work, and you'll have to explain it several times before your grandma understands what you do.